(Bought from GOG Games).
On both of my Macs (one is a year old running 11.5.2 (Big Sur) the other is a 2016 vintage, running 12.0.1 (Monterey) the game won’t launch. It goes through the usual Paizo/Owlcat screens and then gets on to the main loading screen.
The progress bar goes to about 60% and then stays there until I kill the process (I left it for an hour at one point).
This has only happened since the last game update from GOG. Forcing the graphics subsystem to use the higher-spec hardware made no difference at all.
I can’t submit a bug report because it never gets far enough to allow me to get one.